JBS Products: Crystallization Optimization
Do not discard bad diffracting crystals! They can be very useful, too. Try to improve diffraction by varying the solvent content or use your initial crystals for seeding.
Optimize solubility of your protein sample prior to crystallization trials
Covers a broad pH range with several buffer systems
Additive screens containing small molecules which interfere with sample-sample and sample-solvent interactions, primarily based on chaotropic and kosmotropic properties
Advanced detergent screens for solubilization and crystallization of hydrophobic and membrane proteins
Efficient screening for suitable detergents to solubilize hydrophobic and membrane proteins
The 24-hour approach to protein surface engineering - modify crystal contacts by reductive methylation of Lysine residues
In situ proteolysis as rescue technique in protein crystallization
The fastest way for optimization and fine-tuning of initial hits
pH optimization made easy - the most important buffers with pre-adjusted pH and sterile filtered