The New York City Integrative Structural Biology Symposium is October 9-11, 2024. The focus of this workshop is to understand the challenges and opportunities of applying integrative structural biology techniques to one’s research. The fields of light microscopy, mass spectrometry, X-ray crystallography, NMR, cryo-EM, and computational methods will be highlighted. The topics will cover the best practices and current research toward building structural models across different resolution scales. This workshop will also offer hands-on demos to explore what instrumentation is available to be integrated to address conformational changes, flexibility, and dynamics in macromolecular and cellular structures.