Membrane Protein Crystallography

Making crystallization screening of membrane proteins much more efficient and less time consuming.

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  • IMISX KitTM (20)

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    The IMISX™ Plate enables researchers to perform in meso in situ serial X-ray crystallography of soluble and membrane proteins.[1]
    Developed in collaboration with Dr. Martin Caffrey and Dr. Meitian Wang

  • LCP Classic and EZ-CutTM

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    Standard 96-well SBS plates for crystallization of membrane proteins in LCP. Available with either classic thin-glass covers or new EZ-Cut™ polymer cover films.

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  • Accessories for LCP

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    Great results start with the best tools. Proven easy-to-use tools for mixing & dispensing LCP, plus all the accessories you need to do even more.

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  • Amphipol A8-35

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    A short amphipathic polymer that is specifically designed for membrane protein stabilization. The surfactant possesses a very high affinity for the transmembrane surfaces and allows to solubilize membrane proteins in a detergent-free aqueous solution[1].

    Amount: 50 mg

    Shipping: shipped at ambient temperature

    Storage Conditions: store at -20 °C

    Shelf Life: 12 months

    Molecular Formula: (C6.2H10.3O1.35N0.65Na0.35)35

    Molecular Weight: approx. 8 kDa

    CAS#: 1423685-21-5

    Stabilizing agent in Cryo-EM[2-5] and X-ray crystallography[6]

    Selected References:
    [1] Zoonens et al. (2014) Amphipols for Each Season. J Membrane Biol 247:759.
    [2] Chen et al. (2016) Structure of the STRA6 receptor for retinol uptake. Science 353:887.
    [3] Zubcevic et al. (2016) Cryo-Electron Microscopy of the Trpv2 Ion Channel. Nat Struct Mol Biol 23:180.
    [4] Bai et al. (2015) Sampling the conformational space of the catalytic subunit of human gamma-secretase. DOI 10.7554/eLife.11182.
    [5] Althoff et al. (2011) Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1. EMBO J 30:4652.
    [6] Polovinkin et al. (2014) High-Resolution Structure of a Membrane Protein Transferred from Amphipol to a Lipidic Mesophase. J Membrane Biol 247:997.

  • CrystalCube Plate by Cube Biotech

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    Fully automatable method, compatible with any nanoliter robot
    Combines LCP with vapor diffusion to increase success rate
    Requires low protein concentrations (2-5 mg/ml)
    Suitable for use under UV and polarized light


  • JBScreen LCP

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    JBScreen LCP is a crystallization screen designed for efficient screening of crystallization conditions in the Lipidic Cubic Phase (LCP), which has become the method of choice for membrane protein crystallization in different types of LCP lipids.

  • JBScreen Membrane

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    Optimized for hydrophobic and membrane proteins.
    Use the most successful conditions for preliminary screening of your membrane proteins!
    JBScreen Membrane covers 96 of the most successful conditions for crystallization of membrane proteins. Each individual composition results from an extensive analysis of the crystallization conditions that have yielded membrane protein structures so far.

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  • LCP Screens

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    Rigaku wizard kit

    The tools in the Wizard Cubic LCP (lipidic cubic phase) Kit enable researchers to prepare LCP-type crystallizations by hand. Ideal for low-protein experiments: effective protein volume for a single crystallization experiment is about 80 nanoliters

  • Starter Kits for LCP

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    The most complete bundles to help you get started with LCP!

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