JCSG Screens
The JCSG Screen Series provides a comprehensive, strategically designed set of crystallization screens for efficient exploration of diverse protein crystallization conditions. These screens offer complementary approaches to broad initial screening, condition optimization, and cryogenic crystallization. Together, these screens provide researchers with a versatile and streamlined toolkit for increasing the likelihood of identifying high-quality protein crystals for structural studies.
Product Information
JCSG Screens (such as JCSG-plus™ and JCSG++) are premier, highly optimized sparse matrix crystallization screening kits designed for the rapid identification of initial crystallization leads for biological macromolecules, including proteins, peptides, and nucleic acids.
Key Features & Design
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Optimized Sparse Matrix: Formulated using empirical data and results from the Joint Center for Structural Genomics (JCSG) and European genomics consortia to cover a broad, effective chemical space with minimal redundancy.
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Broad pH Range: Operates across a versatile pH range from 4.0 to 10.0 to suit diverse protein stabilities and isoelectric points.
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Comprehensive Chemical Space: Efficiently samples classic PEG and salt conditions, modern precipitants (such as neutralized organic acids), organics, polyalcohols, and a full range of salts spanning the Hofmeister series.
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Method Compatibility: Compatible with all standard crystallization techniques, including sitting drop, hanging drop, microbatch, and high-throughput automated dispensing systems.