JBScreen Plus is an additive screen for optimization of preliminary crystallization conditions. The selection of the additives is based upon the Hofmeister series, which orders ions based upon their ability to stabilize protein structure.Full Description
JBScreen Plus is an additive screen for optimization of preliminary crystallization conditions. The selection of the additives is based upon the Hofmeister series, which orders ions based upon their ability to stabilize protein structure. Ions can be classified as either kosmotropic or chaotropic. The first have structure stabilizing properties, and may assist in, e.g. crystallizing proteins with a large proportion of flexible loop regions. The latter have structure disturbing properties, and may assist in the crystallization of large complexes, allowing them to re-arrange to form favorable crystal contacts.
JBScreen Plus consists of 5 individual kits, JBScreen Plus Kosmotropic, JBScreen PlusChaotropic, JBScreen Plus Salts, JBScreen Plus Additives and JBScreen Plus Volatiles, containing 24 different additives each. The ready-to-use reagents are supplied in 1 ml aliquots.
The 96 solutions of JBScreen Plus HTS, comprising the reagents of the kosmotropic, chaotropic, salts and additive kits, are supplied in a sterile deep well block containing either 200 µl (JBScreen Plus HTS S) or 1 ml (JBScreen Plus HTS L).
JBScreen Plus HTS S is particularly designed for low volume users. The screening reagents can be added directly to the additives in the deep well block before starting a vapor diffusion experiment, while JBScreen Plus HTS L will enable you to transfer any desired volume of additive solution to your plate.
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Note: These are special order items with 2-4 weeks delivery , during our initial phase of carrying Jena products. If you would like us to stock these items, please let us know!