XP Screens – Intelligent Crystal Screens

XP Screens promote protein crystallization even for most challenging targets and improve diffraction quality of protein crystals. The XP Screens are TEW-optimized JBScreen Basics: 96 of the most prominent crystallization conditions complemented with TEW as “glue” for protein molecules.

There are two variations of the XP Screens:

The XP Screen, SKU M-CS-350, is a convenient initial screen that has successfully induced protein crystallization with low TEW concentrations such as 1 mM. In some cases however, higher concentration of 5 or 10 mM TEW are needed.

The XP Up Screen, SKU M-CS-351, is an upgrade of the well-established XP Screen. It contains 96 of the most prominent screening solutions that are long-term stable in the presence of up to 10 mM TEW.

The Anderson-Evans Polyoxotungstate (TEW), SKU M-X-TEW-5, is a universal and flexible crystallization additive that is integrated the XP Screens. It was shown to improve crystal quality and resolution.

Learn More About The XP Screens

SKU: M-CS-351$829.00
SKU: M-CS-350$442.00
SKU: M-X-TEW-5$534.21

Product Information

The Advantages of XP Screens include:

  • Convenient initial screening with up to 10 mM TEW
  • Improved crystal quality and resolution
  • Tight crystal contacts
  • New crystal forms (e.g to provide access to binding pockets)
  • Direct phasing

The Anderson-Evans Polyoxotungstate [TeW6 O24] 6- (TEW), SKU M-X-TEW-5,  is a universal and flexible crystallization additive that is integrated in the XP Screens. It was shown to improve crystal quality and resolution by:

  • Binding to the protein surface and forming tight crystal lattice contacts[3-7]
  • Acting as linker in various orientations and thereby creating either smaller
    (PDB: 4OUA) or larger (PDB: 4PHI) protein-protein distances[3,4]
  • Heterogeneous crystallization of two different protein forms in one single crystal
    (PDB: 4OUA)[4]
  • Inducing new crystal forms with access to the active site (PDB: 6ZDK, 6ZDL, 6ZFA)[5]
  • Covalently binding and structurally adapting to fit into protein molecules
    (PDB: 4Z12, 4Z13)[2]